"Tooms" - a longstanding member of the Clearswift MimeSweeper forums, has published a comprehensive guide for integrating SpamAssassin with MimeSweeper for SMTP (version 5 upwards). This gives you such benefits as:

  • Plugins such as DCC, Pyzor, Razor, Fuzzy OCR
  • Award winning anti-spam engine
  • Well documented, many forums for support
  • Open Source (and free)

I would recommend a beefy server for this though, SpamAssassin is known for being somewhat greedy with system resources.

The guide is on Tooms's homepage - here.